human CASP6 shRNA silencing AAV

Cat. No: shAAV-204120

Availability: 4-5 weeks

Name: AAV-h-CASP6-shRNA

This is an AAV expressing shRNA for silencing of Human CASP6.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CASP6
Gene Name: caspase 6
Gene ID: 839
Gene Synonyms: MCH2
ORF Size: 882 bp
RefSeq#: NM_001226
Gene Description: CASP6 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.
UniGene ID: Hs.654616
HGNC ID: HGNC:1507