human CAMKK2 shRNA silencing AAV

Cat. No: shAAV-204005

Availability: 4-5 weeks

Name: AAV-h-CAMKK2-shRNA

This is an AAV expressing shRNA for silencing of Human CAMKK2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CAMKK2
Gene Name: calcium/calmodulin dependent protein kinase kinase 2
Gene ID: 10645
Gene Synonyms: CAMKK; CAMKKB
ORF Size: 1626 bp
RefSeq#: NM_153499
Gene Description: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
UniGene ID: Hs.297343
HGNC ID: HGNC:1470