human CABLES1 shRNA silencing AAV

Cat. No: shAAV-203892

Availability: 4-5 weeks

Name: AAV-h-CABLES1-shRNA

This is an AAV expressing shRNA for silencing of Human CABLES1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CABLES1
Gene Name: Cdk5 and Abl enzyme substrate 1
Gene ID: 91768
Gene Synonyms: CABL1; CABLES; HsT2563; IK3-1
ORF Size: 1107 bp
RefSeq#: NM_138375
Gene Description: CABLES1 encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.11108
HGNC ID: HGNC:25097