human BRWD1 shRNA silencing AAV

Cat. No: shAAV-202291

Availability: 4-5 weeks

Name: AAV-h-BRWD1-shRNA

This is an AAV expressing shRNA for silencing of Human BRWD1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BRWD1
Gene Name: bromodomain and WD repeat domain containing 1
Gene ID: 54014
Gene Synonyms: C21orf107; DCAF19; N143; WDR9
ORF Size: 360 bp
RefSeq#: NM_018963
Gene Description: BRWD1 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. BRWD1 is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.
UniGene ID: Hs.654740
HGNC ID: HGNC:12760