human BPNT1 shRNA silencing AAV

Cat. No: shAAV-202245

Availability: 4-5 weeks

Name: AAV-h-BPNT1-shRNA

This is an AAV expressing shRNA for silencing of Human BPNT1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BPNT1
Gene Name: 3'(2'), 5'-bisphosphate nucleotidase 1
Gene ID: 10380
Gene Synonyms: HEL20; PIP
ORF Size: 978 bp
RefSeq#: NM_006085
Gene Description: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
UniGene ID: Hs.406134
HGNC ID: HGNC:1096