human BOLA3 shRNA silencing AAV

Cat. No: shAAV-202231

Availability: 6-8 weeks

Name: AAV-h-BOLA3-shRNA

This is an AAV expressing shRNA for silencing of Human BOLA3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BOLA3
Gene Name: bolA family member 3
Gene ID: 388962
Gene Synonyms: MMDS2
ORF Size: 321 bp
RefSeq#: NM_212552
Gene Description: BOLA3 encodes a protein that plays an essential role in the production of iron-sulfur (Fe-S) clusters for the normal maturation of lipoate-containing 2-oxoacid dehydrogenases, and for the assembly of the mitochondrial respiratory chain complexes. Mutation in this gene has been associated with multiple mitochondrial dysfunctions syndrome-2. Two alternatively spliced transcript variants encoding different isoforms with distinct subcellular localization have been reported for this gene (PMID:21944046).
UniGene ID: Hs.61472
HGNC ID: HGNC:24415