human BBC3 shRNA silencing AAV

Cat. No: shAAV-201991

Availability: 4-5 weeks

Name: AAV-h-BBC3-shRNA

This is an AAV expressing shRNA for silencing of Human BBC3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BBC3
Gene Name: BCL2 binding component 3
Gene ID: 27113
Gene Synonyms: JFY-1; JFY1; PUMA
ORF Size: 582 bp
RefSeq#: NM_014417
Gene Description: BBC3 encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
UniGene ID: Hs.467020
HGNC ID: HGNC:17868