human BAK1 shRNA silencing AAV

Cat. No: shAAV-201953

Availability: 4-5 weeks

Name: AAV-h-BAK1-shRNA

This is an AAV expressing shRNA for silencing of Human BAK1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: BAK1
Gene Name: BCL2 antagonist/killer 1
Gene ID: 578
Gene Synonyms: BAK; BAK-LIKE; BCL2L7; CDN1
ORF Size: 636 bp
RefSeq#: NM_001188
Gene Description: BAK1 belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
UniGene ID: Hs.485139
HGNC ID: HGNC:949