human AUP1 shRNA silencing AAV

Cat. No: shAAV-201826

Availability: 6-8 weeks

Name: AAV-h-AUP1-shRNA

This is an AAV expressing shRNA for silencing of Human AUP1.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: AUP1
Gene Name: ancient ubiquitous protein 1
Gene ID: 550
ORF Size: 1122 bp
RefSeq#: NM_181575
Gene Description: AUP1 encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. AUP1 overlaps the gene for mitochondrial serine protease 25.
UniGene ID: Hs.411480
HGNC ID: HGNC:891