human ATP6V1E1 shRNA silencing AAV

Cat. No: shAAV-201765

Availability: 4-5 weeks

Name: AAV-h-ATP6V1E1-shRNA

This is an AAV expressing shRNA for silencing of Human ATP6V1E1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ATP6V1E1
Gene Name: ATPase H+ transporting V1 subunit E1
Gene ID: 529
Gene Synonyms: ATP6E; ATP6E2; ATP6V1E; P31; Vma4
ORF Size: 681 bp
RefSeq#: NM_001696
Gene Description: ATP6V1E1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. ATP6V1E1 encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.
UniGene ID: Hs.517338
HGNC ID: HGNC:857