human ATP5J shRNA silencing AAV

Cat. No: shAAV-201729

Availability: 4-5 weeks

Name: AAV-h-ATP5J-shRNA

This is an AAV expressing shRNA for silencing of Human ATP5J.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ATP5J
Gene Name: ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6
Gene ID: 522
Gene Synonyms: ATP5; ATP5A; ATPM; CF6; F6
ORF Size: 327 bp
RefSeq#: NM_001685
Gene Description: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11.
UniGene ID: Hs.246310
HGNC ID: HGNC:847