human ATG4B shRNA silencing AAV

Cat. No: shAAV-201641

Availability: 4-5 weeks

Name: AAV-h-ATG4B-shRNA

This is an AAV expressing shRNA for silencing of Human ATG4B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ATG4B
Gene Name: autophagy related 4B cysteine peptidase
Gene ID: 23192
Gene Synonyms: APG4B; AUTL1
ORF Size: 1182 bp
RefSeq#: NM_013325
Gene Description: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniGene ID: Hs.283610
HGNC ID: HGNC:20790