human ASL shRNA silencing AAV

Cat. No: shAAV-201559

Availability: 4-5 weeks

Name: AAV-h-ASL-shRNA

This is an AAV expressing shRNA for silencing of Human ASL.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ASL
Gene Name: argininosuccinate lyase
Gene ID: 435
Gene Synonyms: ASAL
ORF Size: 1395 bp
RefSeq#: NM_000048
Gene Description: ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
UniGene ID: Hs.632015
HGNC ID: HGNC:746