human ARNT2 shRNA silencing AAV

Cat. No: shAAV-201451

Availability: 4-5 weeks

Name: AAV-h-ARNT2-shRNA

This is an AAV expressing shRNA for silencing of Human ARNT2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ARNT2
Gene Name: aryl hydrocarbon receptor nuclear translocator 2
Gene ID: 9915
Gene Synonyms: bHLHe1; WEDAS
ORF Size: 2151 bp
RefSeq#: NM_014862
Gene Description: ARNT2 encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.
UniGene ID: Hs.459070
HGNC ID: HGNC:16876