human ARHGEF7 shRNA silencing AAV

Cat. No: shAAV-201374

Availability: 4-5 weeks

Name: AAV-h-ARHGEF7-shRNA

This is an AAV expressing shRNA for silencing of Human ARHGEF7.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ARHGEF7
Gene Name: Rho guanine nucleotide exchange factor 7
Gene ID: 8874
Gene Synonyms: BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB
ORF Size: 2262 bp
RefSeq#: NM_003899
Gene Description: Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniGene ID: Hs.508738
HGNC ID: HGNC:15607