human APPL1 shRNA silencing AAV

Cat. No: shAAV-201223

Availability: 4-5 weeks

Name: AAV-h-APPL1-shRNA

This is an AAV expressing shRNA for silencing of Human APPL1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: APPL1
Gene Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Gene ID: 26060
Gene Synonyms: APPL; DIP13alpha; MODY14
ORF Size: 2130 bp
RefSeq#: NM_012096
Gene Description: APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
UniGene ID: Hs.476415
HGNC ID: HGNC:24035