human APOL1 shRNA silencing AAV

Cat. No: shAAV-201203

Availability: 6-8 weeks

Name: AAV-h-APOL1-shRNA

This is an AAV expressing shRNA for silencing of Human APOL1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: APOL1
Gene Name: apolipoprotein L1
Gene ID: 8542
Gene Synonyms: APO-L; APOL; APOL-I; FSGS4
ORF Size: 1197 bp
RefSeq#: NM_003661
Gene Description: APOL1 encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.114309
HGNC ID: HGNC:618