human APH1A shRNA silencing AAV

Cat. No: shAAV-201143

Availability: 4-5 weeks

Name: AAV-h-APH1A-shRNA

This is an AAV expressing shRNA for silencing of Human APH1A.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: APH1A
Gene Name: aph-1 homolog A, gamma-secretase subunit
Gene ID: 51107
Gene Synonyms: 6530402N02Rik; APH-1; APH-1A; CGI-78
ORF Size: 798 bp
RefSeq#: NM_016022
Gene Description: APH1A encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
UniGene ID: Hs.108408
HGNC ID: HGNC:29509