human APEX2 shRNA silencing AAV

Cat. No: shAAV-201142

Availability: 4-5 weeks

Name: AAV-h-APEX2-shRNA

This is an AAV expressing shRNA for silencing of Human APEX2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: APEX2
Gene Name: apurinic/apyrimidinic endodeoxyribonuclease 2
Gene ID: 27301
Gene Synonyms: APE2; APEXL2; XTH2; ZGRF2
ORF Size: 1557 bp
RefSeq#: NM_014481
Gene Description: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
UniGene ID: Hs.659558
HGNC ID: HGNC:17889