human APC shRNA silencing AAV

Cat. No: shAAV-201126

Availability: 4-5 weeks

Name: AAV-h-APC-shRNA

This is an AAV expressing shRNA for silencing of Human APC.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: APC
Gene Name: APC, WNT signaling pathway regulator
Gene ID: 324
Gene Synonyms: BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
ORF Size: 8532 bp
RefSeq#: NM_000038
Gene Description: APC encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
UniGene ID: Hs.158932
HGNC ID: HGNC:583