human ANTXR1 shRNA silencing AAV

Cat. No: shAAV-201035

Availability: 4-5 weeks

Name: AAV-h-ANTXR1-shRNA

This is an AAV expressing shRNA for silencing of Human ANTXR1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ANTXR1
Gene Name: anthrax toxin receptor 1
Gene ID: 84168
Gene Synonyms: ATR; GAPO; TEM8
ORF Size: 1002 bp
RefSeq#: NM_018153
Gene Description: ANTXR1 encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
UniGene ID: Hs.165859
HGNC ID: HGNC:21014