human AMPD1 shRNA silencing AAV

Cat. No: shAAV-200869

Availability: 6-8 weeks

Name: AAV-h-AMPD1-shRNA

This is an AAV expressing shRNA for silencing of Human AMPD1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: AMPD1
Gene Name: adenosine monophosphate deaminase 1
Gene ID: 270
Gene Synonyms: MAD; MADA; MMDD
ORF Size: 2241 bp
RefSeq#: NM_000036
Gene Description: Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
UniGene ID: Hs.89570
HGNC ID: HGNC:468