human ALDOA shRNA silencing AAV

Cat. No: shAAV-200753

Availability: 4-5 weeks

Name: AAV-h-ALDOA-shRNA

This is an AAV expressing shRNA for silencing of Human ALDOA.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ALDOA
Gene Name: aldolase, fructose-bisphosphate A
Gene ID: 226
Gene Synonyms: ALDA; GSD12; HEL-S-87p
ORF Size: 1095 bp
RefSeq#: NM_000034
Gene Description: ALDOA, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
UniGene ID: Hs.513490
HGNC ID: HGNC:414