human ADRBK2 shRNA silencing AAV

Cat. No: shAAV-200512

Availability: 4-5 weeks

Name: AAV-h-ADRBK2-shRNA

This is an AAV expressing shRNA for silencing of Human GRK3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GRK3
Gene Name: G protein-coupled receptor kinase 3
Gene ID: 157
Gene Synonyms: ADRBK2; BARK2
ORF Size: 1164 bp
RefSeq#: NM_005160
Gene Description: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
UniGene ID: Hs.657494
HGNC ID: HGNC:290