human ACO1 shRNA silencing AAV

Cat. No: shAAV-200198

Availability: Immediate

Name: AAV-h-ACO1-shRNA

This is an AAV expressing shRNA for silencing of Human ACO1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACO1
Gene Name: aconitase 1
Gene ID: 48
Gene Synonyms: ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
ORF Size: 2670 bp
RefSeq#: NM_002197
Gene Description: Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
UniGene ID: Hs.567229
HGNC ID: HGNC:117