human ACMSD shRNA silencing AAV

Cat. No: shAAV-200194

Availability: 4-5 weeks

Name: AAV-h-ACMSD-shRNA

This is an AAV expressing shRNA for silencing of Human ACMSD.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACMSD
Gene Name: aminocarboxymuconate semialdehyde decarboxylase
Gene ID: 130013
ORF Size: 1011 bp
RefSeq#: NM_138326
Gene Description: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.(supplied by OMIM, Oct 2004)
UniGene ID: Hs.655728
HGNC ID: HGNC:19288