human ACLY shRNA silencing AAV

Cat. No: shAAV-200193

Availability: 4-5 weeks

Name: AAV-h-ACLY-shRNA

This is an AAV expressing shRNA for silencing of Human ACLY.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACLY
Gene Name: ATP citrate lyase
Gene ID: 47
Gene Synonyms: ACL; ATPCL; CLATP
ORF Size: 3306 bp
RefSeq#: NM_001096
Gene Description: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
UniGene ID: Hs.387567
HGNC ID: HGNC:115