human ACE2 shRNA silencing AAV

Cat. No: shAAV-200183

Availability: 6-8 weeks

Name: AAV-h-ACE2-shRNA

This is an AAV expressing shRNA for silencing of Human ACE2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACE2
Gene Name: angiotensin I converting enzyme 2
Gene ID: 59272
Gene Synonyms: ACEH
ORF Size: 2418 bp
RefSeq#: NM_021804
Gene Description: ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
UniGene ID: Hs.178098
HGNC ID: HGNC:13557