human ACACA shRNA silencing AAV

Cat. No: shAAV-200146

Availability: 4-5 weeks

Name: AAV-h-ACACA-shRNA

This is an AAV expressing shRNA for silencing of Human ACACA.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACACA
Gene Name: acetyl-CoA carboxylase alpha
Gene ID: 31
Gene Synonyms: ACAC; ACACAD; ACC; ACC1; ACCA
ORF Size: 7152 bp
RefSeq#: NM_198834
Gene Description: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
UniGene ID: Hs.160556
HGNC ID: HGNC:84