human ABO shRNA silencing AAV

Cat. No: shAAV-200132

Availability: 6-8 weeks

Name: AAV-h-ABO-shRNA

This is an AAV expressing shRNA for silencing of Human ABO.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ABO
Gene Name: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
Gene ID: 28
Gene Synonyms: A3GALNT; A3GALT1; GTB; NAGAT
ORF Size: 1065 bp
RefSeq#: NM_020469
Gene Description: ABO encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene.
UniGene ID: Hs.654423
HGNC ID: HGNC:79