human ABHD12 shRNA silencing AAV

Cat. No: shAAV-200108

Availability: 6-8 weeks

Name: AAV-h-ABHD12-shRNA

This is an AAV expressing shRNA for silencing of Human ABHD12.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ABHD12
Gene Name: abhydrolase domain containing 12
Gene ID: 26090
Gene Synonyms: ABHD12A; BEM46L2; C20orf22; dJ965G21.2; PHARC
ORF Size: 1215 bp
RefSeq#: NM_015600
Gene Description: ABHD12 encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
UniGene ID: Hs.441550
HGNC ID: HGNC:15868