human ABCE1 shRNA silencing AAV

Cat. No: shAAV-200090

Availability: 4-5 weeks

Name: AAV-h-ABCE1-shRNA

This is an AAV expressing shRNA for silencing of Human ABCE1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ABCE1
Gene Name: ATP binding cassette subfamily E member 1
Gene ID: 6059
Gene Synonyms: ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI; RNS4I
ORF Size: 1800 bp
RefSeq#: NM_002940
Gene Description: ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
UniGene ID: Hs.12013
HGNC ID: HGNC:69