human ABCD3 shRNA silencing AAV

Cat. No: shAAV-200088

Availability: 4-5 weeks

Name: AAV-h-ABCD3-shRNA

This is an AAV expressing shRNA for silencing of Human ABCD3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ABCD3
Gene Name: ATP binding cassette subfamily D member 3
Gene ID: 5825
Gene Synonyms: ABC43; CBAS5; PMP70; PXMP1; ZWS2
ORF Size: 1650 bp
RefSeq#: NM_002858
Gene Description: ABCD3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniGene ID: Hs.700576
HGNC ID: HGNC:67