human ABCC1 shRNA silencing AAV

Cat. No: shAAV-200071

Availability: 4-5 weeks

Name: AAV-h-ABCC1-shRNA

This is an AAV expressing shRNA for silencing of Human ABCC1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ABCC1
Gene Name: ATP binding cassette subfamily C member 1
Gene ID: 4363
Gene Synonyms: ABC29; ABCC; GS-X; MRP; MRP1
ORF Size: 4596 bp
RefSeq#: NM_004996
Gene Description: ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
UniGene ID: Hs.709181
HGNC ID: HGNC:51