human ABCB7 shRNA silencing AAV

Cat. No: shAAV-200062

Availability: 4-5 weeks

Name: AAV-h-ABCB7-shRNA

This is an AAV expressing shRNA for silencing of Human ABCB7.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ABCB7
Gene Name: ATP binding cassette subfamily B member 7
Gene ID: 22
Gene Synonyms: ABC7; ASAT; Atm1p; EST140535
ORF Size: 2262 bp
RefSeq#: NM_004299
Gene Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
UniGene ID: Hs.370480
HGNC ID: HGNC:48