human AASS shRNA silencing AAV

Cat. No: shAAV-200037

Availability: 6-8 weeks

Name: AAV-h-AASS-shRNA

This is an AAV expressing shRNA for silencing of Human AASS.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: AASS
Gene Name: aminoadipate-semialdehyde synthase
Gene ID: 10157
Gene Synonyms: LKR/SDH; LKRSDH; LORSDH
ORF Size: 2778 bp
RefSeq#: NM_005763
Gene Description: AASS encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.
UniGene ID: Hs.156738
HGNC ID: HGNC:17366