human AARS shRNA silencing AAV

Cat. No: shAAV-200028

Availability: 4-5 weeks

Name: AAV-h-AARS-shRNA

This is an AAV expressing shRNA for silencing of Human AARS.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: AARS
Gene Name: alanyl-tRNA synthetase
Gene ID: 16
Gene Synonyms: CMT2N; EIEE29
ORF Size: 2907 bp
RefSeq#: NM_001605
Gene Description: The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
UniGene ID: Hs.315137
HGNC ID: HGNC:20