human AANAT shRNA silencing AAV

Cat. No: shAAV-200024

Availability: 6-8 weeks

Name: AAV-h-AANAT-shRNA

This is an AAV expressing shRNA for silencing of Human AANAT.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: AANAT
Gene Name: aralkylamine N-acetyltransferase
Gene ID: 15
Gene Synonyms: DSPS; SNAT
ORF Size: 624 bp
RefSeq#: NM_001088
Gene Description: AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.431417
HGNC ID: HGNC:19