Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Mitf

Gene Name

microphthalmia-associated transcription factor

Gene ID

17342

Gene Synonyms

BCC2; Bhlhe32; bw; Gsfbcc2; mi; vit; Vitiligo; Wh

ORF Size

1260 bp

RefSeq#

BC108976

Gene Description

Transcription factor for tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) that plays a key role in melanocyte development. Binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') found in the tyrosinase promoter. Plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

UniGene ID

Mm.454504