Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Grb2

Gene Name

growth factor receptor bound protein 2

Gene ID

14784

Gene Synonyms

AA408164; Ash

ORF Size

654 bp

RefSeq#

BC052377

Gene Description

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway|Function: Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

UniGene ID

Mm.439649