Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Cflar

Gene Name

CASP8 and FADD-like apoptosis regulator

Gene ID

12633

Gene Synonyms

2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; MRIT

ORF Size

1446 bp

RefSeq#

BC029223

Gene Description

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

UniGene ID

Mm.336848