Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Bcl2

Gene Name

B cell leukemia/lymphoma 2

Gene ID

12043

Gene Synonyms

AW986256; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik

ORF Size

711 bp

RefSeq#

BC095964

Gene Description

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

UniGene ID

Mm.477249