Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

DGCR8

Gene Name

DGCR8, microprocessor complex subunit

Gene ID

54487

Gene Synonyms

C22orf12; DGCRK6; Gy1; pasha

ORF Size

2223 bp

RefSeq#

BC078147

Gene Description

DGCR8 encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.

UniGene ID

Hs.643452

HGNC ID

HGNC:2847