Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

TTL

Gene Name

tubulin tyrosine ligase

Gene ID

150465

ORF Size

1134 bp

RefSeq#

BC036819

Gene Description

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 (PubMed 14571137)).(supplied by OMIM, Mar 2008)

UniGene ID

Hs.358997

HGNC ID

HGNC:21586