Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SPINT2

Gene Name

serine peptidase inhibitor, Kunitz type 2

Gene ID

10653

Gene Synonyms

DIAR3; HAI-2; HAI2; Kop; PB

ORF Size

759 bp

RefSeq#

BC011955

Gene Description

SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. SPINT2 is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.31439

HGNC ID

HGNC:11247