Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SH2B3

Gene Name

SH2B adaptor protein 3

Gene ID

10019

Gene Synonyms

IDDM20; LNK

ORF Size

1728 bp

RefSeq#

BC136451

Gene Description

SH2B3 encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.

UniGene ID

Hs.506784

HGNC ID

HGNC:29605