Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PROM1

Gene Name

prominin 1

Gene ID

8842

Gene Synonyms

AC133; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4

ORF Size

2571 bp

RefSeq#

BC012089

Gene Description

PROM1 encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. PROM1 is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.614734

HGNC ID

HGNC:9454