Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PCSK2

Gene Name

proprotein convertase subtilisin/kexin type 2

Gene ID

5126

Gene Synonyms

NEC 2; NEC-2; NEC2; PC2; SPC2

ORF Size

1917 bp

RefSeq#

BC005815

Gene Description

PCSK2 encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. PCSK2 may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniGene ID

Hs.315186

HGNC ID

HGNC:8744