Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

NMNAT1

Gene Name

nicotinamide nucleotide adenylyltransferase 1

Gene ID

64802

Gene Synonyms

LCA9; NMNAT; PNAT1

ORF Size

840 bp

RefSeq#

BC014943

Gene Description

NMNAT1 encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15.

UniGene ID

Hs.633762

HGNC ID

HGNC:17877