Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

NDE1

Gene Name

nudE neurodevelopment protein 1

Gene ID

54820

Gene Synonyms

HOM-TES-87; LIS4; MHAC; NDE; NUDE; NUDE1

ORF Size

1008 bp

RefSeq#

BC001421

Gene Description

NDE1 encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants.

UniGene ID

Hs.655378

HGNC ID

HGNC:17619